Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP14 | P50281 | 13/20 | 0.54 |
| ▸ | MMP3 | P08254 | 13/20 | 0.54 |
| ▸ | MMP9 | P14780 | 13/20 | 0.54 |
| ▸ | MMP8 | P22894 | 10/20 | 0.54 |
| ▸ | MMP1 | P03956 | 10/20 | 0.54 |
| ▸ | MMP13 | P45452 | 9/20 | 0.54 |
| ▸ | MMP7 | P09237 | 3/20 | 0.50 |
| ▸ | MMP10 | P09238 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433976 | 0.93 | MMP3 (0.54) | MMP14MMP3MMP9MMP8MMP1 | |
| Sulfuric Acid SCHEMBL7435746 | 0.93 | MMP3 (0.60) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7422005 | 0.93 | MMP3 (0.62) | MMP14MMP3MMP9MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL6694876 | 0.92 | MMP3 (0.61) | MMP14MMP3MMP9MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7429978 | 0.84 | MMP3 (0.59) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7428734 | 0.81 | MMP3 (0.58) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7431421 | 0.81 | MMP3 (0.58) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7426230 | 0.81 | MMP3 (0.57) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7425849 | 0.78 | MMP3 (0.67) | MMP14MMP3MMP9MMP8MMP1 | |
| SCHEMBL7427208 | 0.78 | MMP3 (0.50) | MMP14MMP3MMP9MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |