Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 2/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14151813 | 0.76 | BACE1 (0.32) | DUT | |
| SCHEMBL17304708 | 0.72 | — | — | |
| SCHEMBL6996010 | 0.70 | HRH3 (0.45) | HRH4HRH1 | |
| SCHEMBL13508322 | 0.70 | FDPS (0.56) | HRH4HRH1FDPSBAZ2B | |
| SCHEMBL21634887 | 0.70 | PYGL (0.42) | HRH4HRH1 | |
| SCHEMBL16886098 | 0.69 | HRH4 (0.50) | HRH4HRH1FDPSBAZ2B | |
| SCHEMBL28709031 | 0.69 | DUT (0.38) | DUT | |
| SCHEMBL2647015 | 0.68 | DUT (0.31) | DUT | |
| SCHEMBL16254673 | 0.67 | RET (0.35) | HRH4 | |
| SCHEMBL15249199 | 0.67 | TYRO3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986562-A1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050385-A1 | SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1998-11-12 | — | — | WO | disclosed |