Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.76 |
| ▸ | PPARD | Q03181 | 7/20 | 0.64 |
| ▸ | PPARG | P37231 | 6/20 | 0.64 |
| ▸ | PPARA | Q07869 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.57 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.56 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433371 | 0.86 | NR1H4 (1.00) | NR1H4MEN1KMT2ADEGS1NPC1 | |
| SCHEMBL7426358 | 0.86 | KMT2A (0.58) | NR1H4PPARDPPARGPPARAMEN1 | |
| SCHEMBL27795055 | 0.85 | PLG (0.60) | NR1H4MEN1KMT2ASENP1DEGS1 | |
| SCHEMBL27852778 | 0.83 | MEN1 (0.57) | NR1H4MEN1KMT2ASENP1DEGS1 | |
| SCHEMBL368228 | 0.82 | DEGS1 (0.78) | NR1H4MEN1KMT2ADEGS1NPC1 | |
| SCHEMBL31150345 | 0.82 | DEGS1 (0.78) | NR1H4MEN1KMT2ADEGS1NPC1 | |
| SCHEMBL7787096 | 0.79 | MEN1 (0.64) | NR1H4MEN1KMT2AHPSEDEGS1 | |
| SCHEMBL3063305 | 0.78 | ALDH1A1 (0.55) | NR1H4PPARDPPARGPPARAMEN1 | |
| SCHEMBL7432018 | 0.78 | NR1H4 (0.82) | NR1H4PPARDPPARGPPARAMEN1 | |
| SCHEMBL344529 | 0.78 | MAPK1 (0.68) | NR1H4MEN1KMT2ADEGS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061631-A1 | MODIFIED PENTAPEPTIDE ANTAGONISTS OF THE ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |