Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 1.00 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.60 |
| ▸ | PLG | P00747 | 2/20 | 0.58 |
| ▸ | KLK1 | P06870 | 2/20 | 0.58 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.58 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427460 | 0.86 | NR1H4 (0.76) | NR1H4DEGS1NPC1RAB9AMEN1 | |
| SCHEMBL7433413 | 0.85 | NR1H4 (0.74) | NR1H4DEGS1FFAR1NPC1RAB9A | |
| SCHEMBL368228 | 0.85 | DEGS1 (0.78) | NR1H4DEGS1NPC1RAB9AMEN1 | |
| SCHEMBL31150345 | 0.85 | DEGS1 (0.78) | NR1H4DEGS1NPC1RAB9AMEN1 | |
| SCHEMBL18132588 | 0.82 | FFAR1 (0.73) | NR1H4FFAR1MEN1KMT2ABCAT2 | |
| SCHEMBL26889396 | 0.82 | DEGS1 (0.79) | NR1H4DEGS1POLBNPC1RAB9A | |
| SCHEMBL3659132 | 0.81 | DEGS1 (0.72) | NR1H4DEGS1FFAR1POLBNPC1 | |
| SCHEMBL10102771 | 0.81 | FFAR1 (0.71) | NR1H4FFAR1POLBNPC1RAB9A | |
| SCHEMBL7890743 | 0.80 | DEGS1 (1.00) | NR1H4DEGS1POLBNPC1RAB9A | |
| SCHEMBL29519104 | 0.80 | DEGS1 (1.00) | NR1H4DEGS1POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061631-A1 | MODIFIED PENTAPEPTIDE ANTAGONISTS OF THE ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |