SCHEMBL74275

SCHEMBL74275

[CH](Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.67
CALM1 P0DP23 1/20 0.50
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
ARG2 P78540 1/20 0.48
TSHR P16473 3/20 0.45
IDO1 P14902 3/20 0.45
ALDH1A1 P00352 2/20 0.45
LOXL2 Q9Y4K0 2/20 0.45
TP53 P04637 1/20 0.45
TRPA1 O75762 1/20 0.45
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
CASP1 P29466 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 2/20 0.41
CYP2A6 P11509 1/20 0.41
HTR2A P28223 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9826758 0.87 MAOB (0.52) MAOBCA1CA2ARG2TSHR
SCHEMBL7041057 0.84 MAOB (0.50) MAOBCA1CA2ARG2IDO1
SCHEMBL13733896 0.84 FNTA (0.54) MAOBCA1CA2ARG2IDO1
SCHEMBL9770101 0.84 LMNA (0.50) MAOBTSHRIDO1ALDH1A1TP53
SCHEMBL365818 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2
SCHEMBL7301824 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2
SCHEMBL3755335 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2
SCHEMBL185486 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2
SCHEMBL118087 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2
SCHEMBL1005335 0.83 MAOB (0.55) MAOBCALM1CA1CA2ARG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112831335-B Method for preparing mesophase pitch and mesophase carbon microspheres from heavy oil 中国石油大学(华东) 2022-05-10 CN claimed
CN-112831334-A Preparation method of mesophase pitch and mesophase carbon microspheres 中国石油大学(华东) 2021-05-25 CN claimed
CN-112831335-A Method for preparing mesophase pitch and mesophase carbon microspheres from heavy oil 中国石油大学(华东) 2021-05-25 CN claimed
US-20170313661-A1 KINASE MODULATORS FOR THE TREATMENT OF CANCER SYNOVO GMBH (DE) 2017-11-02 US claimed
US-9416123-B2 Kinase modulators for the treatment of cancer SYNOVO GMBH (DE) 2016-08-16 US claimed
US-20140336225-A1 KINASE MODULATORS FOR THE TREATMENT OF CANCER SYNOVO GMBH (DE) 2014-11-13 US claimed
CN-102066442-B Polymacromonomer and process for production thereof EXXONMOBIL CHEM PATENTS INC 2013-10-02 CN claimed
EP-2078002-B1 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS MERCK SHARP & DOHME (US) 2013-08-28 EP claimed
WO-2013078240-A1 N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG RIPKA AMY S (US) 2013-05-30 WO claimed
WO-2013046041-A1 PYRIDINYLPYRAZOLES FOR USE AS KINASE MODULATORS FOR THE TREATMENT OF CANCER SYNOVO GMBH (DE) 2013-04-04 WO claimed
US-5246969-A Oligopeptides as renin inhibitors G. D. SEARLE & CO. (US) 1993-09-21 US claimed
US-5118688-A TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS ICI AMERICAS INC. (US) 1992-06-02 US claimed
US-4976889-A 4-formylaminopiperidine derivatives, their use as stabilizers and organic material stabilized with the said derivatives BASF AKTIENGESELLSCHAFT (DE) 1990-12-11 US claimed
EP-0363284-A2 Use of peptidase inhibitors for the preparation of medicaments useful for the treatment of strokes MERRELL PHARMACEUTICALS INC. (US) 1990-04-11 EP claimed
EP-0183191-B1 THIENYLTHIAZOLE COMPOUNDS Yoshitomi Pharmaceutical Industries, Ltd. (JP) 1989-05-10 EP claimed
EP-0230151-A2 Cholecystokinin antagonists BIOMEASURE, INC. (US) 1987-07-29 EP claimed
US-4521412-A Pesticidal iodopropargylammonium salts BAYER AKTIENGESELLSCHAFT (DE) 1985-06-04 US claimed
US-4220649-A VASODILATORS AND HYPOTENSIVE AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1980-09-02 US claimed
US-4100344-A BACTERICIDES E. R. SQUIBB & SONS, INC. (US) 1978-07-11 US claimed
US-4028354-A BACTERICIDES E. R. SQUIBB & SONS, INC. (US) 1977-06-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170313661-A1 KINASE MODULATORS FOR THE TREATMENT OF CANCER MAP3K10, MAP3K12, MAP3K20 MAOB 4305/4885CALM1 577/4885CA1 3348/4885
US-20140336225-A1 KINASE MODULATORS FOR THE TREATMENT OF CANCER DCK, MAP3K2, MAP3K19 MAOB 4144/4885CALM1 621/4885CA1 4030/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.