Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771066 | 0.86 | POLB (0.49) | MAPTALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL3759997 | 0.84 | POLB (0.48) | MAPTALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL5082865 | 0.81 | L3MBTL1 (0.46) | ALDH1A1KDM4ERAB9ANPC1USP2 | |
| SCHEMBL3988422 | 0.79 | PDK1 (0.42) | MAPTALDH1A1POLB | |
| SCHEMBL3980303 | 0.77 | HSD11B1 (0.40) | ALDH1A1SMN1; SMN2HPGDPOLB | |
| SCHEMBL1516144 | 0.76 | MAPT (0.82) | MAPTFKBP1AALDH1A1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL68316 | 0.74 | MAPT (0.79) | MAPTFKBP1AALDH1A1KMT2AKDM4E | |
| SCHEMBL3119026 | 0.73 | GAA (0.55) | MAPTFKBP1AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3122088 | 0.73 | FKBP1A (0.51) | MAPTFKBP1AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16345665 | 0.73 | MAPT (0.63) | MAPTFKBP1AKMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073624-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | Proteus Molecular Design Limited (GB) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055661-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | PROTEUS MOLECULAR DESIGN LIMITED (GB) | 1999-11-04 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |