Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428987 | 0.94 | LMNA (0.43) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7538643 | 0.93 | F2 (0.40) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7428080 | 0.80 | MET (0.43) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7430917 | 0.79 | MET (0.47) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7421294 | 0.78 | LMNA (0.46) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7420425 | 0.77 | F2 (0.42) | HCRTR1HCRTR2METLMNARAB9A | |
| SCHEMBL7433951 | 0.77 | L3MBTL1 (0.43) | HCRTR1HCRTR2LMNARAB9ANPC1 | |
| SCHEMBL7427220 | 0.76 | F10 (0.54) | — | |
| SCHEMBL7542208 | 0.75 | LMNA (0.47) | LMNARAB9ANPC1TP53GAA | |
| SCHEMBL7432661 | 0.73 | LMNA (0.47) | HCRTR1HCRTR2LMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |