Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423860 | 0.87 | SORT1 (0.44) | ALDH1A1GRNSORT1 | |
| SCHEMBL7417318 | 0.79 | CNR2 (0.40) | ALDH1A1GRNSORT1MME | |
| SCHEMBL1655302 | 0.78 | CTSK (0.62) | HDAC1HDAC8HDAC6GRNSORT1 | |
| SCHEMBL5869312 | 0.77 | ALDH1A1 (0.42) | ALDH1A1PPARGPPARANPC1POLB | |
| SCHEMBL6930381 | 0.77 | ALDH1A1 (0.42) | ALDH1A1PPARGPPARANPC1POLB | |
| SCHEMBL7377704 | 0.77 | GRN (0.43) | ALDH1A1GRNSORT1CTSKMME | |
| SCHEMBL7378949 | 0.76 | MME (0.50) | ALDH1A1CTSKMME | |
| SCHEMBL7429293 | 0.75 | SORT1 (0.34) | ALDH1A1GRNSORT1POLB | |
| SCHEMBL7421108 | 0.74 | SORT1 (0.42) | ALDH1A1GRNSORT1 | |
| SCHEMBL5869970 | 0.74 | PPARG (0.46) | HDAC1HDAC8HDAC6ALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |