Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 2/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421108 | 0.89 | SORT1 (0.42) | SORT1ALDH1A1DHFRMAPK1GRN | |
| SCHEMBL7425447 | 0.82 | DHFR (0.34) | SORT1ALDH1A1DHFRMMP2CYP2C19 | |
| SCHEMBL7426920 | 0.80 | CTSK (0.38) | SORT1ALDH1A1DHFRMMP2CYP2C19 | |
| SCHEMBL5869629 | 0.77 | ACE2 (0.39) | SORT1ALDH1A1MMP2CYP2C19MAPK1 | |
| SCHEMBL7423334 | 0.76 | DHFR (0.34) | SORT1ALDH1A1DHFRMMP2CYP2C19 | |
| SCHEMBL7421752 | 0.76 | MEN1 (0.39) | ALDH1A1CYP2C19KMT2AMEN1 | |
| SCHEMBL7428133 | 0.75 | HDAC1 (0.40) | SORT1ALDH1A1POLBGRN | |
| SCHEMBL7417292 | 0.74 | ALDH1A1 (0.34) | SORT1ALDH1A1CYP2C19MAPK1TAS1R3 | |
| SCHEMBL7423860 | 0.74 | SORT1 (0.44) | SORT1ALDH1A1MAPK1GRN | |
| SCHEMBL7426736 | 0.73 | CTSK (0.48) | SORT1ALDH1A1CYP2C19MAPK1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |