Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761347 | 0.84 | GNAO1 (0.41) | OPRM1SIGMAR1 | |
| SCHEMBL9845960 | 0.84 | SIGMAR1 (0.41) | SMN1; SMN2OPRM1CHRM5CHRM3SIGMAR1 | |
| SCHEMBL10386726 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 | |
| SCHEMBL13833229 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 | |
| SCHEMBL713548 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 | |
| SCHEMBL2945288 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 | |
| SCHEMBL22248563 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 | |
| SCHEMBL9420793 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL9420761 | 0.76 | SMN1; SMN2 (0.35) | SMN1; SMN2 | |
| SCHEMBL991697 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM5CHRM3SIGMAR1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109023-A1 | Isoquinolinesulfonamide derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-05-23 | — | — | EP | disclosed |