Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 10/20 | 0.45 |
| ▸ | CTSS | P25774 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 3/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422599 | 0.84 | GRN (0.47) | CTSKCTSSCTSLPTGFRCTSB | |
| SCHEMBL7424899 | 0.83 | CTSK (0.50) | CTSKCTSSCTSLCYP2C19CTSB | |
| SCHEMBL7420947 | 0.80 | CTSK (0.45) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7420340 | 0.80 | MAPT (0.44) | CTSKCTSSCTSLPTGFR | |
| SCHEMBL7378949 | 0.79 | MME (0.50) | CTSKCTSSCYP2C19 | |
| SCHEMBL7421831 | 0.77 | NTSR1 (0.54) | AKR1C3AKR1C2CTSKCTSSCTSL | |
| SCHEMBL5870370 | 0.75 | FOLH1 (0.49) | CTSKCYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL5870357 | 0.75 | FOLH1 (0.49) | CTSKCYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL5870344 | 0.75 | FOLH1 (0.49) | CTSKCYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL7425598 | 0.74 | KMT2A (0.41) | CTSKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |