Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.50 |
| ▸ | CTSS | P25774 | 12/20 | 0.50 |
| ▸ | CTSL | P07711 | 10/20 | 0.50 |
| ▸ | CTSB | P07858 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424801 | 0.89 | CTSS (0.46) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL7422599 | 0.85 | GRN (0.47) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL7428422 | 0.83 | AKR1C3 (0.45) | CTSKCTSSCTSLCTSBCYP2C19 | |
| SCHEMBL7420947 | 0.83 | CTSK (0.45) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7378949 | 0.82 | MME (0.50) | CTSKCTSSALDH1A1CYP2C19 | |
| SCHEMBL7421831 | 0.80 | NTSR1 (0.54) | CTSKCTSSCTSLNTSR1 | |
| SCHEMBL7420340 | 0.78 | MAPT (0.44) | CTSKCTSSCTSLALDH1A1 | |
| SCHEMBL4039064 | 0.78 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL4310706 | 0.78 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL4309572 | 0.78 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |