Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427117 | 0.88 | MEN1 (0.52) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL7042609 | 0.85 | MEN1 (0.48) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL7428439 | 0.84 | MEN1 (0.48) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL7481625 | 0.82 | CTSK (0.39) | SMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL7426096 | 0.80 | CTSK (0.54) | — | |
| SCHEMBL7538673 | 0.80 | ATM (0.49) | KDM4EMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7427121 | 0.79 | MEN1 (0.55) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL6897906 | 0.79 | CTSK (0.53) | MEN1KMT2APKM | |
| SCHEMBL7533624 | 0.79 | CTSK (0.42) | RAB9ASMN1; SMN2ALDH1A1GAACYP1A2 | |
| SCHEMBL7042614 | 0.78 | MEN1 (0.51) | MEN1KMT2AKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |