Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096603 | 0.85 | HSD17B10 (0.45) | ATMGAAALDH1A1HSD17B10LMNA | |
| SCHEMBL7538681 | 0.84 | ATM (0.49) | ATMGAAALDH1A1HSD17B10LMNA | |
| SCHEMBL7533624 | 0.83 | CTSK (0.42) | GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7426096 | 0.83 | CTSK (0.54) | — | |
| SCHEMBL7428434 | 0.80 | MEN1 (0.48) | GAAALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL7481625 | 0.79 | CTSK (0.39) | GAAALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL5096605 | 0.79 | CTSK (0.50) | ATMGAAALDH1A1HSD17B10LMNA | |
| SCHEMBL6897906 | 0.78 | CTSK (0.53) | — | |
| SCHEMBL7424838 | 0.76 | CTSK (0.34) | — | |
| SCHEMBL4767047 | 0.73 | CTSK (0.42) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |