Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.42 |
| ▸ | CTSL | P07711 | 7/20 | 0.42 |
| ▸ | CTSS | P25774 | 7/20 | 0.42 |
| ▸ | CTSB | P07858 | 5/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096354 | 0.85 | CTSK (0.43) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7426096 | 0.85 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7533634 | 0.85 | CTSK (0.42) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7538673 | 0.83 | ATM (0.49) | GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7481625 | 0.80 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5096358 | 0.79 | CTSK (0.53) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7428434 | 0.79 | MEN1 (0.48) | GAAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6897906 | 0.77 | CTSK (0.53) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7424838 | 0.76 | CTSK (0.34) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5093270 | 0.75 | CTSK (0.52) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |