Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430527 | 0.94 | PDK1 (0.34) | NPC1RAB9AHDAC1MAPK14AVPR2 | |
| SCHEMBL7430920 | 0.93 | PDK1 (0.34) | NPC1RAB9AHDAC1MAPK14AVPR2 | |
| SCHEMBL5210913 | 0.85 | NPC1 (0.39) | NPC1RAB9AHDAC1MAPK14NR1H4 | |
| SCHEMBL5210889 | 0.85 | NPC1 (0.40) | NPC1RAB9AHDAC1MAPK14OPRM1 | |
| SCHEMBL5210074 | 0.84 | RXRB (0.38) | NPC1RAB9AHDAC1MAPK14NR1H4 | |
| Trifluoroacetic Acid SCHEMBL4807978 | 0.84 | NPC1 (0.37) | NPC1RAB9AHDAC1MAPK14SMN1; SMN2 | |
| SCHEMBL5216930 | 0.83 | RAB9A (0.37) | NPC1RAB9AHDAC1MAPK14SMN1; SMN2 | |
| SCHEMBL7131862 | 0.80 | RXRA (0.36) | NPC1RAB9AMAPK14OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL7427799 | 0.80 | MAPK14 (0.36) | NPC1RAB9AMAPK14OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL7128388 | 0.80 | RXRA (0.36) | NPC1RAB9AMAPK14OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |