Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.58 |
| ▸ | MMP13 | P45452 | 18/20 | 0.58 |
| ▸ | MMP2 | P08253 | 18/20 | 0.58 |
| ▸ | MMP14 | P50281 | 7/20 | 0.58 |
| ▸ | MMP1 | P03956 | 6/20 | 0.58 |
| ▸ | MMP9 | P14780 | 5/20 | 0.58 |
| ▸ | MMP8 | P22894 | 3/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
| ▸ | MMP7 | P09237 | 1/20 | 0.58 |
| ▸ | MMP10 | P09238 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359550 | 0.91 | ADAM17 (0.60) | ADAM17MMP13MMP2MMP14MMP1 | |
| Trifluoroacetic Acid SCHEMBL7942839 | 0.85 | ADAM17 (0.54) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL7429048 | 0.81 | MMP13 (0.58) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL3940023 | 0.77 | MMP2 (0.79) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL7301710 | 0.76 | MMP1 (0.80) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL3984079 | 0.76 | MMP1 (0.80) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL7308448 | 0.75 | MMP1 (0.81) | ADAM17MMP13MMP2MMP14MMP1 | |
| SCHEMBL7306093 | 0.75 | MMP1 (0.81) | ADAM17MMP13MMP2MMP14MMP1 | |
| Hydrochloric Acid SCHEMBL7349688 | 0.74 | MMP13 (0.77) | ADAM17MMP13MMP2MMP14MMP1 | |
| Cts-1027 SCHEMBL2381112 | 0.74 | MMP1 (1.00) | ADAM17MMP13MMP2MMP14MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077974-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058528-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY. (US) | 1999-11-18 | — | — | WO | disclosed |