Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.81 |
| ▸ | HTT | P42858 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.74 |
| ▸ | LMNA | P02545 | 7/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | XBP1 | P17861 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757527 | 0.85 | KDM4E (0.73) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL6204720 | 0.78 | KDM4E (0.74) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL3755596 | 0.77 | KDM4E (0.73) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL3756523 | 0.76 | KDM4E (0.58) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL31615154 | 0.76 | MAPT (0.84) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL3759099 | 0.75 | KDM4E (0.79) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL13058217 | 0.75 | KDM4E (0.58) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL4926416 | 0.74 | MAPT (0.72) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL6267038 | 0.74 | MAPT (0.87) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL4923684 | 0.74 | LMNA (0.75) | MAPTKDM4EHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | MAPT 2323/4885KDM4E 1876/4885HTT 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.