Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.55 |
| ▸ | ACE | P12821 | 6/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.52 |
| ▸ | CPA1 | P15085 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421402 | 0.92 | MMP1 (0.55) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL8763014 | 0.85 | MME (0.50) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL15692334 | 0.80 | MME (0.65) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL30777486 | 0.80 | MME (0.65) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL7365144 | 0.79 | ACE (0.73) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL15649671 | 0.79 | MME (0.67) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL15692372 | 0.79 | MME (0.67) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL8005905 | 0.78 | MME (0.87) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL30051692 | 0.78 | LTA4H (0.67) | MMEACEACE2CPA1MMP2 | |
| SCHEMBL8005357 | 0.77 | MME (0.65) | MMEACEACE2CPA1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | claimed |
| US-6180611-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR | DARWIN DISCOVERY, LTD. (GB) | 2001-01-30 | — | — | US | disclosed |
| EP-1047450-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| US-5994312-A | Peptidyl compounds | DARWIN DISCOVERY, LTD. (GB) | 1999-11-30 | — | — | US | disclosed |
| WO-1999032150-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | disclosed |