Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.55 |
| ▸ | MMP2 | P08253 | 6/20 | 0.50 |
| ▸ | MMP9 | P14780 | 6/20 | 0.50 |
| ▸ | MMP8 | P22894 | 6/20 | 0.50 |
| ▸ | NMBR | P28336 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | IL1RN | P18510 | 3/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488102 | 0.84 | MMP1 (0.47) | MMP1MMP2MMP9MMP8REN | |
| SCHEMBL7887257 | 0.83 | MMP1 (0.66) | MMP1MMP2MMP9MMP8ERAP2 | |
| SCHEMBL6413967 | 0.83 | MMP1 (0.66) | MMP1MMP2MMP9MMP8ERAP2 | |
| SCHEMBL7895827 | 0.83 | MMP1 (0.66) | MMP1MMP2MMP9MMP8ERAP2 | |
| SCHEMBL7482029 | 0.80 | MMP1 (0.41) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL7420777 | 0.78 | MMP1 (0.41) | MMP1MMP2MMP9REN | |
| SCHEMBL7426256 | 0.78 | MMP1 (0.54) | MMP1MMP2MMP9MMP8REN | |
| SCHEMBL8390442 | 0.78 | ERAP2 (0.59) | MMP1ECE1IL1RNERAP2ERAP1 | |
| SCHEMBL7763613 | 0.77 | REN (0.44) | MMP1MMP2MMP9MMP8NMBR | |
| SCHEMBL7384431 | 0.77 | REN (0.46) | MMP2MMP9MMP8NMBRREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047450-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032150-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |