Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 10/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 8/20 | 0.42 |
| ▸ | CASP7 | P55210 | 6/20 | 0.42 |
| ▸ | CASP9 | P55211 | 2/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439016 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7438266 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7436207 | 0.92 | CYP1A2 (0.47) | CASP1CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL7436931 | 0.92 | CASP1 (0.48) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7495339 | 0.91 | SMN1; SMN2 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7492068 | 0.91 | SMN1; SMN2 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7444952 | 0.91 | SMN1; SMN2 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7427222 | 0.91 | SMN1; SMN2 (0.52) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 | |
| SCHEMBL7444131 | 0.88 | CASP1 (0.43) | CASP1CYP1A2CYP2C9CYP2C19CASP3 | |
| SCHEMBL7436378 | 0.86 | LMNA (0.47) | ALDH1A1LMNAHTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |