Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 11/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437530 | 0.92 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7432175 | 0.92 | CYP1A2 (0.48) | ALDH1A1TP53CASP1CYP1A2CYP2C9 | |
| SCHEMBL7427222 | 0.92 | SMN1; SMN2 (0.52) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7427204 | 0.91 | LMNA (0.44) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7434939 | 0.88 | SMN1; SMN2 (0.57) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7444224 | 0.88 | CASP1 (0.45) | TP53CASP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7432223 | 0.87 | SMN1; SMN2 (0.55) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7438266 | 0.86 | ALDH1A1 (0.46) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7429462 | 0.86 | ALDH1A1 (0.46) | LMNAALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL7439016 | 0.86 | ALDH1A1 (0.46) | LMNAALDH1A1SMN1; SMN2HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |