Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 10/20 | 0.43 |
| ▸ | PPARA | Q07869 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576876 | 0.86 | KMT2A (0.56) | POLBKMT2AACACBKDM4ELDHA | |
| SCHEMBL24884682 | 0.77 | POLB (0.59) | POLBKMT2AACACBKDM4ELDHA | |
| SCHEMBL19759402 | 0.74 | POLB (0.60) | POLBKMT2AACACBKDM4ELDHA | |
| SCHEMBL2803084 | 0.74 | POLB (0.60) | POLBKMT2AACACBKDM4ELDHA | |
| SCHEMBL7698662 | 0.72 | RIPK1 (0.42) | KMT2APPARA | |
| SCHEMBL21445775 | 0.72 | POLB (0.54) | POLBKMT2AACACBNR1H4KDM4E | |
| SCHEMBL7698659 | 0.72 | RIPK1 (0.42) | KMT2APPARA | |
| SCHEMBL7698664 | 0.72 | RIPK1 (0.42) | KMT2APPARA | |
| SCHEMBL5317079 | 0.72 | LDHA (0.69) | POLBKMT2AACACBLDHANPC1 | |
| SCHEMBL22111634 | 0.72 | POLB (0.53) | POLBKMT2AACACBKDM4ELDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133484-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000005223-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |