Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31663340 | 0.81 | TSHR (0.50) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL8803148 | 0.81 | L3MBTL1 (0.48) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL5900467 | 0.80 | L3MBTL1 (0.44) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL7428453 | 0.72 | ALDH1A1 (0.52) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL7825993 | 0.71 | L3MBTL1 (0.47) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL27834208 | 0.71 | L3MBTL1 (0.52) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL27834209 | 0.70 | L3MBTL1 (0.55) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL22587293 | 0.70 | POLB (0.50) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL7421184 | 0.69 | DPP4 (0.43) | ALDH1A1KDM4EMEN1KMT2ARXFP1 | |
| SCHEMBL31663230 | 0.68 | L3MBTL1 (0.49) | L3MBTL1TSHRALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |