Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362431 | 0.84 | RAB9A (0.49) | MAPTALDH1A1TDP1RECQLRAB9A | |
| SCHEMBL362286 | 0.83 | CA12 (0.46) | MAPTALDH1A1TDP1RECQLRAB9A | |
| SCHEMBL362429 | 0.83 | CYP19A1 (0.38) | MAPTALDH1A1LMNATDP1RECQL | |
| SCHEMBL25412944 | 0.83 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7973046 | 0.82 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2947864 | 0.81 | LMNA (0.45) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7518552 | 0.80 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10352701 | 0.78 | CYP19A1 (0.55) | MAPTALDH1A1KMT2ALMNATDP1 | |
| SCHEMBL16943483 | 0.78 | VCAM1 (0.48) | MAPTALDH1A1LMNATDP1RECQL | |
| SCHEMBL27103147 | 0.78 | RAB9A (0.40) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133484-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000005223-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |