Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.79 |
| ▸ | MMP14 | P50281 | 13/20 | 0.79 |
| ▸ | MMP13 | P45452 | 12/20 | 0.79 |
| ▸ | MMP2 | P08253 | 9/20 | 0.79 |
| ▸ | MMP3 | P08254 | 10/20 | 0.60 |
| ▸ | MMP8 | P22894 | 10/20 | 0.60 |
| ▸ | MMP1 | P03956 | 6/20 | 0.59 |
| ▸ | MMP7 | P09237 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5919254 | 0.88 | MMP9 (1.00) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL7429722 | 0.80 | MMP9 (0.72) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL6621747 | 0.79 | MMP9 (0.63) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL6537294 | 0.77 | MMP14 (0.79) | MMP9MMP14MMP13MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL6684352 | 0.77 | MMP14 (0.78) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL7566235 | 0.76 | MMP9 (0.78) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL5919210 | 0.76 | MMP9 (0.83) | MMP9MMP14MMP13MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL6685477 | 0.76 | MMP9 (0.77) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL5919060 | 0.75 | MMP13 (0.77) | MMP9MMP14MMP13MMP2MMP3 | |
| SCHEMBL5919523 | 0.75 | MMP9 (1.00) | MMP9MMP14MMP13MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |