Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428862 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2AGAAMAPK1TSHR | |
| SCHEMBL7406499 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2AGAAMAPK1TSHR | |
| SCHEMBL7429790 | 0.82 | CXCL8 (0.42) | — | |
| SCHEMBL7429922 | 0.81 | MEN1 (0.38) | MEN1KMT2ANPSR1MAPTKDM4E | |
| SCHEMBL9580715 | 0.77 | TSHR (0.41) | MEN1KMT2ANPSR1MAPTKDM4E | |
| SCHEMBL7372514 | 0.74 | DDB1 (0.48) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL6032361 | 0.74 | L3MBTL1 (0.47) | MEN1KMT2ANPSR1MAPTKDM4E | |
| SCHEMBL31290664 | 0.72 | CYP3A4 (0.50) | MEN1KMT2ANPSR1MAPTKDM4E | |
| SCHEMBL28030373 | 0.71 | CYP3A4 (0.56) | MEN1KMT2ANPSR1MAPTKDM4E | |
| SCHEMBL11648424 | 0.69 | SMN1; SMN2 (0.45) | MEN1KMT2ANPSR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229381-A | Inhibitors of leukocyte enzyme elastase | MERCK & CO., INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0481671-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |