Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193358 | 0.83 | CYP4F2 (0.42) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL7406495 | 0.82 | ALDH1A1 (0.51) | HSD17B10POLBALDH1A1HPGDKDM4E | |
| SCHEMBL9580715 | 0.81 | TSHR (0.41) | MEN1KMT2ACA1CA2HSD17B10 | |
| SCHEMBL7439317 | 0.81 | ELANE (0.43) | CA2HSD17B10TSHRPOLBALDH1A1 | |
| SCHEMBL7434188 | 0.81 | ELANE (0.43) | CA2HSD17B10TSHRPOLBALDH1A1 | |
| SCHEMBL7429786 | 0.81 | ELANE (0.43) | CA2HSD17B10TSHRPOLBALDH1A1 | |
| SCHEMBL7434368 | 0.81 | PPARG (0.36) | KMT2ATRPV1POLBALDH1A1HPGD | |
| SCHEMBL7429925 | 0.81 | MEN1 (0.37) | MEN1KMT2ACA1CA2HSD17B10 | |
| SCHEMBL7368461 | 0.73 | LMNA (0.43) | KMT2APOLBALDH1A1HPGDGAA | |
| SCHEMBL8605131 | 0.73 | ELANE (0.41) | KMT2ACA1CA2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229381-A | Inhibitors of leukocyte enzyme elastase | MERCK & CO., INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0481671-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |