Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022819 | 0.94 | MAPT (0.45) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL11018171 | 0.92 | MAPT (0.47) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL11202315 | 0.90 | MAPT (0.45) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL7359104 | 0.87 | MAPT (0.48) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL11208706 | 0.87 | MAPT (0.48) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL7486243 | 0.85 | ABCB11 (0.42) | MAPTLMNAABCB11MAPK1KMT2A | |
| SCHEMBL7485729 | 0.84 | LMNA (0.39) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL11022009 | 0.84 | LMNA (0.41) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7429080 | 0.83 | MAPT (0.43) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL10876533 | 0.83 | MAPT (0.40) | MAPTLMNAABCB11MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046590-B1 | PHEN(ALK)OXY-SUBSTITUTED OXIRANE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND DRUGS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |
| EP-0046590-A2 | Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-03-03 | — | — | EP | disclosed |