Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424914 | 0.87 | L3MBTL1 (0.43) | NQO2L3MBTL1TP53RAB9ANPC1 | |
| SCHEMBL7430617 | 0.83 | L3MBTL1 (0.49) | L3MBTL1TP53RAB9ANPC1LMNA | |
| SCHEMBL7426351 | 0.83 | L3MBTL1 (0.49) | L3MBTL1TP53RAB9ANPC1LMNA | |
| SCHEMBL7424909 | 0.75 | L3MBTL1 (0.44) | L3MBTL1TP53RAB9ANPC1LMNA | |
| SCHEMBL16067423 | 0.70 | L3MBTL1 (0.72) | L3MBTL1TP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7425441 | 0.69 | L3MBTL1 (0.60) | L3MBTL1TP53RAB9ANPC1LMNA | |
| SCHEMBL7424881 | 0.69 | SLC6A4 (0.52) | L3MBTL1TP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5433980 | 0.69 | NQO2 (1.00) | NQO2L3MBTL1LMNASMN1; SMN2GAA | |
| SCHEMBL7433951 | 0.68 | L3MBTL1 (0.43) | L3MBTL1TP53RAB9ANPC1LMNA | |
| SCHEMBL13130238 | 0.68 | L3MBTL1 (1.00) | L3MBTL1TP53RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |