Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430617 | 0.89 | L3MBTL1 (0.49) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7424914 | 0.85 | L3MBTL1 (0.43) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7426351 | 0.83 | L3MBTL1 (0.49) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7430625 | 0.75 | NQO2 (0.50) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7433951 | 0.72 | L3MBTL1 (0.43) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7425441 | 0.71 | L3MBTL1 (0.60) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7421268 | 0.69 | MAPT (0.60) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL7424249 | 0.68 | LMNA (0.46) | L3MBTL1RAB9ANPC1LMNATP53 | |
| SCHEMBL16067423 | 0.68 | L3MBTL1 (0.72) | L3MBTL1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL7422357 | 0.68 | L3MBTL1 (0.51) | L3MBTL1RAB9ANPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |