Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | SHMT1 | P34896 | 5/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216938 | 1.00 | PTGDR2 (0.38) | PTGDR2SHMT1ACLYMMP2TDP1 | |
| SCHEMBL7210908 | 0.89 | MMP2 (0.38) | PTGDR2SHMT1ACLYMMP2TDP1 | |
| SCHEMBL7215461 | 0.86 | ALDH1A1 (0.44) | PTGDR2SHMT1TDP1SHMT2 | |
| SCHEMBL7212023 | 0.85 | ALDH1A1 (0.39) | PTGDR2SHMT1ACLYTDP1 | |
| SCHEMBL7428969 | 0.79 | MMP2 (0.50) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7424262 | 0.79 | MMP2 (0.50) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7210467 | 0.77 | SHMT1 (0.38) | PTGDR2SHMT1ACLYSHMT2 | |
| SCHEMBL7211219 | 0.77 | SHMT1 (0.37) | PTGDR2SHMT1ACLYTDP1SHMT2 | |
| SCHEMBL7215592 | 0.75 | ALDH1A1 (0.39) | PTGDR2SHMT1TDP1 | |
| SCHEMBL7210468 | 0.73 | MMP2 (0.39) | PTGDR2SHMT1ACLYMMP2SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001038301-A1 | (R)-3-(4-CHLOROBIPHENYL-SULFONYL)-2-HYDROXY-2-(PHENYLTHIO)METHYLPROPIONIC ACID AND ITS USE MATRIX METALLOPROTEINASE | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-05-31 | — | — | WO | disclosed |
| WO-2001038301-A1 | (R)-3-(4-CHLOROBIPHENYL-SULFONYL)-2-HYDROXY-2-(PHENYLTHIO)METHYLPROPIONIC ACID AND ITS USE MATRIX METALLOPROTEINASE | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-05-31 | — | — | WO | disclosed |