Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.50 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428969 | 1.00 | MMP2 (0.50) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7210802 | 0.87 | MMP2 (0.40) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7394619 | 0.85 | PRMT1 (0.52) | MMP2MMP3MMP13ALDH1A1NPC1 | |
| SCHEMBL7398968 | 0.85 | PRMT1 (0.52) | MMP2MMP3MMP13ALDH1A1NPC1 | |
| SCHEMBL7393371 | 0.84 | MMP13 (0.43) | MMP2MMP13MMP1ALDH1A1NPC1 | |
| SCHEMBL7210638 | 0.81 | MMP13 (0.50) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7210895 | 0.81 | MMP9 (0.43) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7216938 | 0.79 | PTGDR2 (0.38) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7430760 | 0.79 | PTGDR2 (0.38) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7212048 | 0.77 | MMP1 (0.45) | MMP2MMP3MMP13MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001038301-A1 | (R)-3-(4-CHLOROBIPHENYL-SULFONYL)-2-HYDROXY-2-(PHENYLTHIO)METHYLPROPIONIC ACID AND ITS USE MATRIX METALLOPROTEINASE | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-05-31 | — | — | WO | disclosed |