Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | PI4KA | P42356 | 3/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436592 | 0.83 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL7440235 | 0.78 | CNOT7 (0.41) | ADORA2AADORA2BGRM5GRM1 | |
| SCHEMBL7440799 | 0.74 | CTSL (0.40) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL7440795 | 0.74 | CTSL (0.40) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL7430898 | 0.73 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL953696 | 0.72 | LMNA (0.51) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6473284 | 0.72 | ADORA2A (0.54) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL30332114 | 0.72 | ADORA2A (0.49) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL786455 | 0.72 | ADORA2A (0.49) | GRIA1GRIA2GRIA3GRIA4ADORA2A | |
| SCHEMBL29602218 | 0.71 | YTHDC1 (0.49) | GRIA1GRIA2GRIA3GRIA4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |