Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 12/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 12/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP27B1 | O15528 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912644 | 0.98 | UBE2M (0.36) | UBE2MDCUN1D1LMNAKMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL10363130 | 0.96 | UBE2M (0.36) | UBE2MDCUN1D1LMNAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9662206 | 0.96 | DCUN1D1 (0.39) | UBE2MDCUN1D1LMNAKMT2AALDH1A1 | |
| SCHEMBL2550638 | 0.87 | LMNA (0.33) | UBE2MDCUN1D1LMNAKMT2AALDH1A1 | |
| SCHEMBL13232295 | 0.81 | ALDH1A1 (0.34) | LMNAKMT2AALDH1A1 | |
| SCHEMBL2979279 | 0.79 | ALDH1A1 (0.35) | LMNAKMT2AALDH1A1 | |
| SCHEMBL21916037 | 0.76 | HTT (0.35) | KMT2AALDH1A1 | |
| SCHEMBL13438298 | 0.76 | MAPK1 (0.41) | UBE2MDCUN1D1LMNAKMT2ACYP1A2 | |
| SCHEMBL9601574 | 0.76 | DCUN1D1 (0.35) | UBE2MDCUN1D1LMNAKMT2AALDH1A1 | |
| SCHEMBL2561990 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017954-A | ANGIOGENESIS INHIBITORS FOR TREATING AND PREVENTING ANGIOGENESIS-DEPENDENT TUMORS, ESPECIALLY KAPOSI'S SARCOMA, BREAST CANCER, COLON CANCER | CHILDREN'S MEDICAL CENTER CORP. (US) | 2000-01-25 | — | — | US | disclosed |
| US-5698586-A | ADMINISTERING AN O-SUBSTITUTED FUMAGILLOL | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0359036-B1 | Fumagillol derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-03-26 | — | — | EP | disclosed |
| EP-0682020-A1 | Fumagillol derivatives useful as angiogenesis inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-11-15 | — | — | EP | disclosed |
| EP-0357061-B1 | Angiogenesis inhibitory agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-5290807-A | Antiinflammatory agents | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| US-5233035-A | Microbiocides | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-08-03 | — | — | US | disclosed |
| US-5180738-A | Angiogenesis Inhibitors | TAKEDA CHEMICAL INDUSTRIES (JP) | 1993-01-19 | — | — | US | disclosed |
| US-5166172-A | Angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5164410-A | Fumagillol derivatives and pharmaceutical compositions thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| EP-0420608-A2 | Cephalosporin derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0359036-A1 | Fumagillol derivatives | Takeda Chemical Industries, Ltd. (JP) | 1990-03-21 | — | — | EP | disclosed |
| EP-0357061-A1 | Angiogenesis inhibitory agent | Takeda Chemical Industries, Ltd. (JP) | 1990-03-07 | — | — | EP | disclosed |