Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | ATP4A | P20648 | 4/20 | 0.47 |
| ▸ | ATP4B | P51164 | 4/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434493 | 0.89 | ATP4A (0.59) | HTR2CATP4AATP4BNPC1RAB9A | |
| SCHEMBL7432599 | 0.83 | HTR2C (0.60) | HTR2CATP4AATP4BRORCNUDT1 | |
| SCHEMBL7440079 | 0.78 | PKM (0.47) | ATP4AATP4BRORCIDO1CYP19A1 | |
| SCHEMBL7441516 | 0.77 | MPL (0.58) | ATP4AATP4BNPC1RAB9AL3MBTL1 | |
| SCHEMBL474398 | 0.76 | MPL (0.54) | HTR2CATP4AATP4BNUDT1NPC1 | |
| SCHEMBL7435953 | 0.76 | ALDH1A1 (0.42) | ATP4AATP4BRAB9AALDH1A1LMNA | |
| SCHEMBL7431101 | 0.75 | HTR2C (0.52) | HTR2CATP4AATP4BRORCNUDT1 | |
| SCHEMBL7437724 | 0.75 | ATP4A (0.61) | ATP4AATP4BNPC1RAB9ACYP19A1 | |
| SCHEMBL7438579 | 0.74 | MAPT (0.51) | NPC1RAB9AL3MBTL1CYP19A1MAPK1 | |
| SCHEMBL7434501 | 0.73 | ALOX5 (0.50) | NPC1RAB9AEIF4EBLMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |