Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 6/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CCKBR | P32239 | 4/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | PLD2 | O14939 | 2/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435423 | 0.87 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4768321 | 0.87 | CCR1 (0.42) | MC4RMC5RMC3RCCR1TAS1R3 | |
| SCHEMBL7534924 | 0.85 | CTSK (0.42) | CCR1CTSKCTSLCTSSCTSB | |
| SCHEMBL7426317 | 0.85 | CTSK (0.37) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7428041 | 0.81 | CTSK (0.41) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5971691 | 0.81 | MAPK1 (0.36) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4823843 | 0.80 | TAS1R3 (0.49) | MC4RCCR1TAS1R3TAS1R1CTSK | |
| SCHEMBL7538204 | 0.79 | TAS1R3 (0.49) | TAS1R3TAS1R1CTSKCTSLCTSS | |
| SCHEMBL6764532 | 0.78 | CTSK (0.33) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4765041 | 0.77 | CTSK (0.43) | TAS1R3TAS1R1CTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |