Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433120 | 1.00 | POLB (0.45) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL7433127 | 1.00 | POLB (0.45) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL8954369 | 0.93 | HSD17B10 (0.46) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL8899635 | 0.85 | RECQL (0.40) | CYP2D6CYP1A2HSD17B10CYP3A4TSHR | |
| SCHEMBL2804427 | 0.84 | CYP2D6 (0.45) | CYP2D6CYP1A2HSD17B10TSHRMAPK1 | |
| SCHEMBL8668280 | 0.83 | CYP2C19 (0.42) | POLBCYP2D6CYP1A2HSD17B10TSHR | |
| SCHEMBL21436384 | 0.80 | SIGMAR1 (0.34) | CYP2D6HSD17B10CYP3A4CYP2C19MEN1 | |
| SCHEMBL8668373 | 0.79 | LMNA (0.40) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL6073531 | 0.79 | SLC6A4 (0.47) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL6074184 | 0.79 | SLC6A4 (0.47) | POLBCYP2D6CYP1A2HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384636-A1 | Pharmaceutically active compounds | FISONS plc (GB) | 1990-08-29 | — | — | EP | disclosed |