Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19354448 | 0.84 | ADRB2 (0.53) | ADRB2ADRB1ADRB3NPC1KDM4E | |
| SCHEMBL14034889 | 0.81 | LMNA (0.59) | ADRB2ADRB1ADRB3ALDH1A1LMNA | |
| SCHEMBL18862636 | 0.81 | MAPK1 (0.55) | ADRB2ADRB1ADRB3ALDH1A1ELANE | |
| SCHEMBL8123928 | 0.79 | KDM4E (0.40) | ADRB2ADRB1ADRB3ALDH1A1ELANE | |
| SCHEMBL29465556 | 0.78 | LMNA (0.62) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL133366 | 0.78 | LMNA (0.62) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL1802562 | 0.77 | ADRB2 (0.55) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL642777 | 0.76 | LMNA (0.61) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| Methane SCHEMBL15286491 | 0.76 | LMNA (0.61) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL1509380 | 0.76 | MAPK1 (0.62) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5210266-A | Analgesic enkephalinase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| US-5179125-A | Analgesics | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| EP-0318859-A2 | N-substituted mercaptopropanamide derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-06-07 | — | — | EP | disclosed |