Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802562 | 0.84 | ADRB2 (0.55) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL1804032 | 0.81 | TDP1 (0.61) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL29465556 | 0.81 | LMNA (0.62) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL133366 | 0.81 | LMNA (0.62) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL1795012 | 0.81 | TDP1 (0.56) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL23484460 | 0.81 | MAPK1 (0.65) | MAPK1HIF1AADRB2ADRB1ADRB3 | |
| SCHEMBL5310805 | 0.79 | TDP1 (0.59) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL19032982 | 0.79 | ADRB2 (0.51) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| SCHEMBL8846567 | 0.79 | SLC7A5 (0.57) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 | |
| Methane SCHEMBL15286491 | 0.79 | LMNA (0.61) | ADRB2ADRB1ADRB3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289962-A2 | Polyurea compositions and compounds for the preparation thereof | Sawyer, Kenneth I. (US) | 2011-03-02 | — | — | EP | claimed |
| US-20080194859-A1 | Polyurea Compositions and Compounds for the Preparation Thereof | Sawyer, Kenneth I. (US) | 2008-08-14 | — | — | US | claimed |
| EP-1751206-A2 | POLYUREA COMPOSITIONS AND COMPOUNDS FOR THE PREPARATION THEREOF | Sawyer, Kenneth I. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113487-A2 | POLYUREA COMPOSITIONS AND COMPOUNDS FOR THE PREPARATION THEREOF | SAWYER KENNETH I (US) | 2005-12-01 | — | — | WO | claimed |
| EP-2289962-A2 | Polyurea compositions and compounds for the preparation thereof | Sawyer, Kenneth I. (US) | 2011-03-02 | — | — | EP | disclosed |
| US-20080194859-A1 | Polyurea Compositions and Compounds for the Preparation Thereof | Sawyer, Kenneth I. (US) | 2008-08-14 | — | — | US | disclosed |
| EP-1751206-A2 | POLYUREA COMPOSITIONS AND COMPOUNDS FOR THE PREPARATION THEREOF | Sawyer, Kenneth I. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113487-A2 | POLYUREA COMPOSITIONS AND COMPOUNDS FOR THE PREPARATION THEREOF | SAWYER KENNETH I (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194859-A1 | Polyurea Compositions and Compounds for the Preparation Thereof | PUF60, PCNA, PARG | MAPK1 4158/4885HIF1A 773/4885ADRB2 4804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.