Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 7/20 | 0.42 |
| ▸ | METAP1 | P53582 | 7/20 | 0.42 |
| ▸ | REN | P00797 | 5/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432793 | 0.85 | METAP2 (0.48) | METAP2METAP1RENPSEN1PSEN2 | |
| SCHEMBL7436027 | 0.76 | REN (0.52) | METAP2METAP1REN | |
| SCHEMBL7433023 | 0.75 | REN (0.47) | METAP2METAP1RENKMT2A | |
| SCHEMBL7433418 | 0.75 | METAP2 (0.39) | METAP2METAP1RENPSEN1PSEN2 | |
| SCHEMBL9727591 | 0.73 | REN (0.47) | METAP2METAP1RENKMT2A | |
| SCHEMBL9727598 | 0.73 | REN (0.47) | METAP2METAP1RENKMT2A | |
| SCHEMBL9260290 | 0.73 | REN (0.50) | METAP2METAP1RENKMT2A | |
| SCHEMBL9728015 | 0.73 | REN (0.44) | METAP2METAP1REN | |
| SCHEMBL9728012 | 0.73 | REN (0.44) | METAP2METAP1REN | |
| SCHEMBL21931658 | 0.72 | METAP2 (0.52) | METAP2METAP1RENATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0391179-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |