Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | USP19 | O94966 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433334 | 0.75 | METAP2 (0.42) | METAP2METAP1PSEN1PSEN2APH1B | |
| SCHEMBL7432793 | 0.72 | METAP2 (0.48) | METAP2METAP1PSEN1PSEN2APH1B | |
| SCHEMBL7436027 | 0.72 | REN (0.52) | METAP2METAP1REN | |
| SCHEMBL7433023 | 0.69 | REN (0.47) | METAP2METAP1RENKMT2A | |
| SCHEMBL9260290 | 0.68 | REN (0.50) | METAP2METAP1RENKMT2A | |
| SCHEMBL21931658 | 0.67 | METAP2 (0.52) | METAP2METAP1RENATMMEN1 | |
| SCHEMBL7429913 | 0.66 | REN (0.47) | METAP2METAP1RENKMT2A | |
| SCHEMBL7272398 | 0.66 | METAP2 (0.51) | METAP2METAP1RENMEN1KMT2A | |
| SCHEMBL7497309 | 0.65 | MMP3 (0.50) | METAP2METAP1RENMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7435572 | 0.64 | MMP3 (0.49) | METAP2METAP1RENMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0391179-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |