Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.48 |
| ▸ | REN | P00797 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577028 | 0.90 | KLK5 (0.47) | KLK5MTNR1AMTNR1B | |
| SCHEMBL7446899 | 0.88 | AAK1 (0.46) | BACE1RENMEN1KMT2A | |
| SCHEMBL10724182 | 0.88 | CTSB (0.45) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL7437679 | 0.85 | PPARG (0.58) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL6579018 | 0.82 | KLK5 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6574905 | 0.82 | KLK5 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6576260 | 0.82 | KLK5 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15866036 | 0.81 | PPARA (0.48) | MEN1KMT2ANPSR1APPKLK5 | |
| SCHEMBL9404273 | 0.81 | MTNR1A (0.64) | MEN1KMT2ANPSR1MTNR1AMTNR1B | |
| SCHEMBL8910228 | 0.81 | MTNR1A (0.64) | MEN1KMT2ANPSR1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |