Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433466 | 0.88 | BACE1 (0.48) | MEN1KMT2ABACE1REN | |
| SCHEMBL10724182 | 0.84 | CTSB (0.45) | MEN1KMT2ABACE1RENCTSS | |
| SCHEMBL6577028 | 0.78 | KLK5 (0.47) | ALDH1A1CA1CA2CA7CTSS | |
| SCHEMBL3863441 | 0.76 | ALDH1A1 (0.56) | AAK1MAPTGAAALDH1A1MEN1 | |
| SCHEMBL7437679 | 0.76 | PPARG (0.58) | MEN1KMT2ABACE1REN | |
| SCHEMBL10422496 | 0.75 | CA1 (0.40) | CA1CA2CA7MEN1KMT2A | |
| SCHEMBL10422711 | 0.73 | CA1 (0.40) | LMNAGAACA1CA2CA7 | |
| SCHEMBL10982144 | 0.73 | CA1 (0.57) | GAACA1CA2CA7BACE1 | |
| SCHEMBL7364723 | 0.73 | CA1 (0.57) | CA1CA2CA7BACE1REN | |
| SCHEMBL12018725 | 0.73 | CA1 (0.57) | CA1CA2CA7BACE1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |