Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.58 |
| ▸ | PPARA | Q07869 | 3/20 | 0.58 |
| ▸ | PPARD | Q03181 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 9/20 | 0.52 |
| ▸ | REN | P00797 | 3/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437488 | 0.88 | PSEN1 (0.49) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL7433466 | 0.85 | BACE1 (0.48) | MEN1KMT2ANPSR1BACE1REN | |
| SCHEMBL9697661 | 0.83 | CTSS (0.54) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL22457536 | 0.81 | PPARA (0.67) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL10722632 | 0.80 | REN (0.59) | BACE1RENKLK5 | |
| SCHEMBL10659588 | 0.80 | REN (0.59) | BACE1RENKLK5 | |
| SCHEMBL7437492 | 0.79 | REN (0.49) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL10664376 | 0.79 | PSEN1 (0.59) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL7429081 | 0.79 | REN (0.49) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL5709671 | 0.79 | PSEN1 (0.59) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |