Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886895 | 1.00 | CTSK (0.43) | CTSKALDH1A1HPGDSMN1; SMN2CTSL | |
| SCHEMBL8886883 | 1.00 | CTSK (0.43) | CTSKALDH1A1HPGDSMN1; SMN2CTSL | |
| SCHEMBL7310572 | 1.00 | CTSK (0.43) | CTSKALDH1A1HPGDSMN1; SMN2CTSL | |
| SCHEMBL7433847 | 0.89 | ALDH1A1 (0.39) | CTSKALDH1A1HPGDSMN1; SMN2CTSL | |
| SCHEMBL7437237 | 0.88 | CAPN1 (0.46) | CTSKRENCTSS | |
| SCHEMBL7437245 | 0.88 | CAPN1 (0.46) | CTSKRENCTSS | |
| SCHEMBL8886890 | 0.87 | ALDH1A1 (0.38) | CTSKALDH1A1HPGDSMN1; SMN2CTSL | |
| SCHEMBL7308007 | 0.86 | SMN1; SMN2 (0.45) | ALDH1A1HPGDSMN1; SMN2RENPSEN1 | |
| SCHEMBL7313668 | 0.86 | SMN1; SMN2 (0.45) | ALDH1A1HPGDSMN1; SMN2RENPSEN1 | |
| SCHEMBL7306659 | 0.85 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |