Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 10/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886890 | 0.98 | ALDH1A1 (0.38) | ALDH1A1HPGDSMN1; SMN2CTSKUSP2 | |
| SCHEMBL8886883 | 0.89 | CTSK (0.43) | ALDH1A1HPGDSMN1; SMN2CTSKCTSL | |
| SCHEMBL7433853 | 0.89 | CTSK (0.43) | ALDH1A1HPGDSMN1; SMN2CTSKCTSL | |
| SCHEMBL8886895 | 0.89 | CTSK (0.43) | ALDH1A1HPGDSMN1; SMN2CTSKCTSL | |
| SCHEMBL7310572 | 0.89 | CTSK (0.43) | ALDH1A1HPGDSMN1; SMN2CTSKCTSL | |
| SCHEMBL7437241 | 0.88 | ALDH1A1 (0.39) | ALDH1A1HPGDSMN1; SMN2CTSKUSP2 | |
| SCHEMBL7313664 | 0.87 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2CTSKUSP2 | |
| SCHEMBL7303678 | 0.85 | CTSL (0.49) | CTSKCTSLCTSBCTSS | |
| SCHEMBL7301797 | 0.84 | CTSK (0.42) | ALDH1A1HPGDSMN1; SMN2CTSKUSP2 | |
| SCHEMBL7303857 | 0.84 | CTSL (0.43) | ALDH1A1CTSKUSP2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |