Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 7/20 | 0.41 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.41 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441328 | 0.85 | KCNN3 (0.62) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7438720 | 0.84 | KCNN3 (0.47) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7440984 | 0.82 | AGTR1 (0.51) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7438363 | 0.82 | KCNN3 (0.45) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7438046 | 0.82 | PDE10A (0.47) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7433829 | 0.82 | KCNN3 (0.45) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7442336 | 0.82 | KCNN3 (0.45) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7444345 | 0.82 | AGTR1 (0.40) | KCNN3KCNN1KCNN2AGTR1AGTR2 | |
| SCHEMBL7437203 | 0.81 | KCNN3 (0.47) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7441634 | 0.80 | KCNN3 (0.46) | KCNN3KCNN1KCNN2CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |