Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645119 | 1.00 | HTR2A (0.47) | HTR2AHTR2CHTR7SLC6A4SLC6A3 | |
| SCHEMBL8642032 | 0.90 | KDM4E (0.55) | SLC6A3 | |
| SCHEMBL8641073 | 0.83 | HTR2A (0.58) | HTR2AHTR2CHTR7SLC6A4SLC6A3 | |
| SCHEMBL8643172 | 0.79 | SIGMAR1 (0.47) | — | |
| SCHEMBL7444169 | 0.76 | HTR2A (0.59) | HTR2AHTR2CHTR7 | |
| SCHEMBL7444179 | 0.76 | HTR2A (0.59) | HTR2AHTR2CHTR7 | |
| SCHEMBL7444174 | 0.76 | HTR2A (0.59) | HTR2AHTR2CHTR7 | |
| SCHEMBL5406963 | 0.75 | DRD2 (0.66) | HTR2A | |
| SCHEMBL14532761 | 0.75 | DRD2 (0.66) | HTR2A | |
| SCHEMBL7373431 | 0.72 | KDM4E (0.66) | SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996010570-A1 | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES | PFIZER INC. (US) | 1996-04-11 | — | — | WO | disclosed |