Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 11/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427267 | 0.84 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9787143 | 0.77 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9787097 | 0.74 | PDE4A (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7436719 | 0.73 | PDE3B (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10638927 | 0.73 | PDE3B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9787421 | 0.73 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10675744 | 0.71 | DRD2 (0.38) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10680809 | 0.69 | DRD2 (0.36) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8866037 | 0.68 | TRPA1 (0.48) | TRPA1CYP3A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL10680981 | 0.68 | DRD2 (0.38) | PDE3BPDE3ATRPA1CYP3A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999365-A | Preventing damage which occurs to heart tissue when oxygen is reintroduced after a heart attack | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-12 | — | — | US | disclosed |
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |